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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIKFYVE All Species: 24.55
Human Site: T124 Identified Species: 60
UniProt: Q9Y2I7 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2I7 NP_055855.2 2098 237108 T124 F G G H D P R T A V Q L R S L
Chimpanzee Pan troglodytes XP_516057 2098 237088 T124 F G G H D P R T A V Q L R S L
Rhesus Macaque Macaca mulatta XP_001108540 2098 237142 T124 F G G H D P R T A V Q L R S L
Dog Lupus familis XP_536048 2100 237099 T125 F G G H D P R T A V Q L R S L
Cat Felis silvestris
Mouse Mus musculus Q9Z1T6 2097 236858 T124 C G G H D P R T A V Q L R S L
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508087 1539 172614
Chicken Gallus gallus XP_421967 2112 239039 T126 L G G H D P R T A V Q L R S L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O96838 1809 204617
Honey Bee Apis mellifera XP_393666 1986 224732 S117 N L R S Y K D S Q L R S Y W M
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P34756 2278 257401 T206 K S A S S S L T A S L S K S F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.1 95.2 N.A. 93.5 N.A. N.A. 53.9 86.2 N.A. N.A. N.A. 28.7 34.1 N.A. N.A.
Protein Similarity: 100 99.9 99.4 97 N.A. 96.3 N.A. N.A. 60.2 91.5 N.A. N.A. N.A. 46.1 53.5 N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 93.3 N.A. N.A. 0 93.3 N.A. N.A. N.A. 0 0 N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 93.3 N.A. N.A. 0 93.3 N.A. N.A. N.A. 0 26.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.9 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 40.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 0 0 70 0 0 0 0 0 0 % A
% Cys: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 60 0 10 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 40 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % F
% Gly: 0 60 60 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 60 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 10 0 0 0 0 10 0 0 0 0 0 0 10 0 0 % K
% Leu: 10 10 0 0 0 0 10 0 0 10 10 60 0 0 60 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % M
% Asn: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 60 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 10 0 60 0 0 0 0 % Q
% Arg: 0 0 10 0 0 0 60 0 0 0 10 0 60 0 0 % R
% Ser: 0 10 0 20 10 10 0 10 0 10 0 20 0 70 0 % S
% Thr: 0 0 0 0 0 0 0 70 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 60 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % W
% Tyr: 0 0 0 0 10 0 0 0 0 0 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _